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• 5월 3주차 Polygenic scoring accuracy varies across the genetic ancestry continuum | Nature GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 | Nature Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer | Nature A draft human pangenome reference | Nature Discovery of target genes and pathways at GWAS loci by pooled single-cell CRISPR screens | Scienc.. 이번 주 논문들 2023. 5. 23.

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  Global detection of human variants and isoforms by deep proteome sequencing Global detection of human variants and isoforms by deep proteome sequencing | Nature Biotechnology Jürgen Cox & Joshua J. Coon Groups 2023, Nature Biotechnology Abstract 샷건 프로테오믹스 실험은 단일 샘플에서 약 10,000개의 인간 단백질을 검출 그러나 개별 단백질은 일반적으로 전체 아미노산의 일부를 나타내는 펩타이드 서열에 의해 식별되는데, (샷건 프로테오믹스는 잘게 자르는 방법이라서) 이에 일반적인 샷건 방법은 다른 단백질 변형과 동질효소를 구별하지 못함. 따라서 단백질 동질효소의 전 세계적인 발견을 위해서는 더 깊은 단백질 서열화가 필요 이 연구에서는 6개의 인간 .. 논문 리뷰/Protein 2023. 5. 11.

• 5월 2주차 Kangas: The Pandas of Computer Vision | by Adhing'a Fredrick | May, 2023 | Heartbeat (comet.ml) Kangas: The Pandas of Computer Vision Introduction heartbeat.comet.ml Can Transformers Improve Time Series Prediction? | by Lucky Brian | Apr, 2023 | How to Start Business (makeanapplike.com) Can Transformers Improve Time Series Prediction? Can Transformers Improve Time Series Prediction how.makeanapp.. Resources/Weekly reading list 2023. 5. 11.

• 5월 2주차 De novo design of protein interactions with learned surface fingerprints | Nature The proteomic landscape of genome-wide genetic perturbations: Cell Efficient evolution of human antibodies from general protein language models | Nature Biotechnology DisP-seq reveals the genome-wide functional organization of DNA-associated disordered proteins | Nature Biotechnology Global detection of human varia.. 이번 주 논문들 2023. 5. 9.

• 5월 1주차 Bridging clinic and wildlife care with AI-powered pan-species computational pathology | Nature Communications Computational approaches streamlining drug discovery | Nature A precision environmental health approach to prevention of human disease | Nature Communications Synthetic data could be better than real data (nature.com) 이번 주 논문들 2023. 5. 8.

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  [Matplotlib] 한글 폰트 사용하기. 나는 윈도우 세팅에서 작업을 할 때, WSL 과 jupyter lab 에서 matplotlib, seaborn 을 가지고 주로 시각화를 진행한다. Matplotlib 에서 폰트를 사용하려면 WSL(Ubuntu) 에 깔려 있어야 하는데, 먼저 대표적인 한글 폰트인 "나눔고딕" 을 설치하는 방법과 우분투에 폰트를 업데이트하는 법을 소개한다. sudo apt-get install fonts-nanum* # 폰트 설치 sudo fc-cache -fv # 캐시 제거 sudo fc-list | grep nanum # 폰트 설치 확인 rm -rf ~/.cache/matplotlib/* # matplotlib 캐시 제거 세팅이 끝났으면 본격적으로 그림을 그려보자. import matplotlib.pyplot as pl.. 데이터/Plotting 2023. 5. 2.

• [Hist2Mol] 데이터 찾기 프로젝트의 목적이 Histopathology 로 부터 Drug molecule 구조를 생성하는 것 이기 때문에, 환자의 histopathology 정보와 더불어 Drug 처리 정보도 필요했다. ( 어떤 drug 인지도 ) Histopathology data : Aspera Faspex (cancerimagingarchive.net) Aspera Faspex faspex.cancerimagingarchive.net https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=&ved=2ahUKEwif9-T-8tH-AhUAqFYBHUk9DE4QFnoECAsQAQ&url=https%3A%2F%2Fwiki.cancerimagingarchive.net%2Fpage.. Resources/Personal Projects 2023. 4. 28.

• [einops] 차원 관리 툴 이제 차원 관리는 einops (yongwookha.github.io) 이제 차원 관리는 einops stupidly easy yongwookha.github.io arogozhnikov/einops: Deep learning operations reinvented (for pytorch, tensorflow, jax and others) (github.com) 데이터/Data Manipulation 2023. 4. 28.

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  Hierarchical multi-omics data integration and modeling predict cell-specific chemical proteomics and drug responses Hierarchical multi-omics data integration and modeling predict cell-specific chemical proteomics and drug responses - ScienceDirect Hierarchical multi-omics data integration and modeling predict cell-specific chemical proteomics and drug responses Drug-induced phenotypes result from biomolecular interactions across various levels of a biological system. Characterization of pharmacological action.. 논문 리뷰/Systems biology 2023. 4. 25.

• 4월 5주차 Foresight in clinical proteomics: current ... | Open Research Europe (europa.eu) Hierarchical multi-omics data integration and modeling predict cell-specific chemical proteomics and drug responses - ScienceDirect The genetic determinants of recurrent somatic mutations in 43,693 blood genomes | Science Advances 이번 주 논문들 2023. 4. 24.

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  Environment Modulates Protein Heterogeneity Through Transcriptional and Translational Stop Codon Miscoding Environment Modulates Protein Heterogeneity Through Transcriptional and Translational Stop Codon Miscoding | bioRxiv Environment Modulates Protein Heterogeneity Through Transcriptional and Translational Stop Codon Miscoding Stop codon miscoding events give rise to longer proteins, which may alter the protein’s function and thereby generate short-lasting phenotypic variability from a single gene... 논문 리뷰/Protein 2023. 4. 12.

• [Archive] Intrinsically Disordered Proteins ( IDPs ) Classification of Intrinsically Disordered Regions and Proteins | Chemical Reviews (acs.org) 논문 리뷰/Protein 2023. 4. 10.