바이오인포6

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  Noninvasive Lung Cancer Early Detection via Deep Methylation Representation Learning Noninvasive Lung Cancer Early Detection via Deep Methylation Representation Learning | Proceedings of the AAAI Conference on Artificial Intelligence 2022, AAAI AnchorDx Medical 기존의 Methylation 을 이용한 cancer detection 방법은 tissue level 의 방법들이 많아서, cfDNA 에 적용하였을 때 discrepancy 가 많았음. 따라서 이 논문에서는 cfDNA ( blood ) -based 방법을 만들고자 함 Dataset : 450K ( Illumina ) microarray Number of samples : 424 ( Train :.. 논문 리뷰/Other topics 2022. 8. 24.

• 5월 3주차 1. Neoantigen quality predicts immunoediting in survivors of pancreatic cancer | Nature 2. People construct simplified mental representations to plan | Nature 3. Single-cell eQTL models reveal dynamic T cell state dependence of disease loci | Nature 4. A natural mutator allele shapes mutation spectrum variation in mice | Nature 5. A knowledge graph to interpret clinical proteomics data | Nature .. 이번 주 논문들 2022. 5. 20.

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  Genetic and chemotherapeutic influences on germline hypermutation Genetic and chemotherapeutic influences on germline hypermutation | Nature 2022, Nature Raheleh Rahbari & Matthew Hurles groups Here we analysed the genome wide sequences of 21,879 families with rare genetic diseases and identified 12 individuals with a hypermutated genome with between two and seven times more de novo single nucleotide variants than expected. In most families (9 out of 12), the .. 논문 리뷰/Other topics 2022. 5. 16.

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  Stepwise-edited, human melanoma models reveal mutations’ effect on tumor and microenvironment Stepwise-edited, human melanoma models reveal mutations’ effect on tumor and microenvironment (science.org) Aviv Regev group 2022. Science 1. Barcoding + pooling -> scRNA-seq ; 2. Genotype 에 따른 cell state progression. 3. cNMF 로 expression program 을 7개로 나눔. 4. 각 cell state 별로 program usage , pseudobulk expression, 그에 따른 GSEA 결과. Tumor microenvironment 분석을 위해 mice model 에서 생성된 tumor 를 가지고 와서 sngle.. 논문 리뷰/Systems biology 2022. 5. 14.

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  5월 1주차 1. Nonlinear mechanics of human mitotic chromosomes | Nature Nonlinear mechanics of human mitotic chromosomes - Nature A method that uses a combination of optical trapping, fluorescence microscopy and microfluidics to analyse the internal structure of chromosomes shows that there is a distinct nonlinear stiffening of the chromosome in response to tension. www.nature.com condensin + TOP2A gene 에 .. 이번 주 논문들 2022. 5. 8.

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  4월 4주차 1. β-Hydroxybutyrate suppresses colorectal cancer | Nature Here we identify a metabolite signalling pathway that provides actionable insights towards this goal. We perform a dietary screen in autochthonous animal models of CRC and find that ketogenic diets exhibit a strong tumour-inhibitory effect. These properties of ketogenic diets are recapitulated by the ketone body β-hydroxybutyrate (BHB), .. 이번 주 논문들 2022. 5. 1.