bioinformatics17

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  CancerVar: An artificial intelligence–empowered platform for clinical interpretation of somatic mutations in cancer CancerVar: An artificial intelligence–empowered platform for clinical interpretation of somatic mutations in cancer (science.org) Science Advances, 2022. Yunzun Zhou group 일반적으로 쓰는 variant 의 clinical implication / significance 를 보여주는 툴이 너무 많은데, 이들을 비교해 보면 일관되지 않은 결과를 나타내는 경우가 많다. 그래서 통일된 툴에 대한 필요성이 부각되는데, 이 논문에서는 12개의 in-house feature ( annotation ) 과 23개의 external tool output + AMP/ASCO/CAP 201.. 논문 리뷰/Other topics 2022. 5. 16.

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  5월 1주차 1. Nonlinear mechanics of human mitotic chromosomes | Nature Nonlinear mechanics of human mitotic chromosomes - Nature A method that uses a combination of optical trapping, fluorescence microscopy and microfluidics to analyse the internal structure of chromosomes shows that there is a distinct nonlinear stiffening of the chromosome in response to tension. www.nature.com condensin + TOP2A gene 에 .. 이번 주 논문들 2022. 5. 8.

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  4월 4주차 1. β-Hydroxybutyrate suppresses colorectal cancer | Nature Here we identify a metabolite signalling pathway that provides actionable insights towards this goal. We perform a dietary screen in autochthonous animal models of CRC and find that ketogenic diets exhibit a strong tumour-inhibitory effect. These properties of ketogenic diets are recapitulated by the ketone body β-hydroxybutyrate (BHB), .. 이번 주 논문들 2022. 5. 1.

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  4월 3주차 1. Chemical reprogramming of human somatic cells to pluripotent stem cells | Nature chemical stimulation by exposure to small molecules offers an alternative approach that can manipulate cell fate in a simple and highly controllable manner8,9,10. However, human somatic cells are refractory to chemical stimulation owing to their stable epigenome2,11,12 and reduced plasticity13,14; Here we demonst.. 이번 주 논문들 2022. 4. 30.

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  Liquid BIOpsy for MiNimal RESidual DiSease Detection in Head and Neck Squamous Cell Carcinoma (LIONESS)—a personalised circulating tumour DNA analysis in head and neck squamous cell carcinoma Liquid BIOpsy for MiNimal RESidual DiSease Detection in Head and Neck Squamous Cell Carcinoma (LIONESS)—a personalised circulating tumour DNA analysis in head and neck squamous cell carcinoma 2022.02 BJC (IF = 7.6) Inivata Methods personalised assay using deep sequencing of up to 48 primer pairs multiplex PCR and targeted NGS. PCR, with a median value of 14,550 copies. combined with a fixed prim.. 논문 리뷰/Other topics 2022. 4. 24.