생물정보학5

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  Drug target prioritization by perturbed gene expression and network information Drug target prioritization by perturbed gene expression and network information | Scientific Reports (nature.com) 2015, Scientific Reports Shroeder group Drug 는 타겟단백질에 붙어서 downstream effector 와 상호작용하여 결과적으로는 암세포의 전사체를 perturb 시킴. 이러한 perturbation 은 약물의 타겟같은 source 에 대한 정보를 제공함. 이 논문에서, 우리는 이러한 perturbation 과 단백질 상호작용 네트워크가 약물 타겟과 주요 pathway 들을 밝힐 수 있다는 것을 연구했음. CMap 에 있는 500여개 약물에 대한 systematic .. 논문 리뷰/Systems biology 2022. 5. 16.

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  5월 1주차 1. Nonlinear mechanics of human mitotic chromosomes | Nature Nonlinear mechanics of human mitotic chromosomes - Nature A method that uses a combination of optical trapping, fluorescence microscopy and microfluidics to analyse the internal structure of chromosomes shows that there is a distinct nonlinear stiffening of the chromosome in response to tension. www.nature.com condensin + TOP2A gene 에 .. 이번 주 논문들 2022. 5. 8.

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  4월 4주차 1. β-Hydroxybutyrate suppresses colorectal cancer | Nature Here we identify a metabolite signalling pathway that provides actionable insights towards this goal. We perform a dietary screen in autochthonous animal models of CRC and find that ketogenic diets exhibit a strong tumour-inhibitory effect. These properties of ketogenic diets are recapitulated by the ketone body β-hydroxybutyrate (BHB), .. 이번 주 논문들 2022. 5. 1.

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  4월 3주차 1. Chemical reprogramming of human somatic cells to pluripotent stem cells | Nature chemical stimulation by exposure to small molecules offers an alternative approach that can manipulate cell fate in a simple and highly controllable manner8,9,10. However, human somatic cells are refractory to chemical stimulation owing to their stable epigenome2,11,12 and reduced plasticity13,14; Here we demonst.. 이번 주 논문들 2022. 4. 30.

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  Liquid BIOpsy for MiNimal RESidual DiSease Detection in Head and Neck Squamous Cell Carcinoma (LIONESS)—a personalised circulating tumour DNA analysis in head and neck squamous cell carcinoma Liquid BIOpsy for MiNimal RESidual DiSease Detection in Head and Neck Squamous Cell Carcinoma (LIONESS)—a personalised circulating tumour DNA analysis in head and neck squamous cell carcinoma 2022.02 BJC (IF = 7.6) Inivata Methods personalised assay using deep sequencing of up to 48 primer pairs multiplex PCR and targeted NGS. PCR, with a median value of 14,550 copies. combined with a fixed prim.. 논문 리뷰/Other topics 2022. 4. 24.