In silico1

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  Stepwise-edited, human melanoma models reveal mutations’ effect on tumor and microenvironment Stepwise-edited, human melanoma models reveal mutations’ effect on tumor and microenvironment (science.org) Aviv Regev group 2022. Science 1. Barcoding + pooling -> scRNA-seq ; 2. Genotype 에 따른 cell state progression. 3. cNMF 로 expression program 을 7개로 나눔. 4. 각 cell state 별로 program usage , pseudobulk expression, 그에 따른 GSEA 결과. Tumor microenvironment 분석을 위해 mice model 에서 생성된 tumor 를 가지고 와서 sngle.. 논문 리뷰/Systems biology 2022. 5. 14.